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Adipocyte-derived small extracellular vesicles

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Fundamental Research Funds for the Central Universities and 1 more
  • Animals1

Outcomes

2

Lifespan

upin mice1

1 study

  1. Adipocyte-derived small extracellular vesicles extend lifespan in mice.

    “Systemic injection of these sEVs significantly improves physical activity and extends the lifespan of aged mice by increasing NAD+ levels.”

    Reviewin aged mice

    Small Extracellular Vesicles Derived from Adipocytes Attenuate Intervertebral Disc Degeneration in Rats by Rejuvenating Senescent Nucleus Pulposus Cells and Endplate Cells by Delivering Exogenous NAMPT

    Oxidative medicine and cellular longevity14 Aug 2021

Intervertebral disc degeneration

downin rats1

1 study

  1. Adipocyte-derived small extracellular vesicles decrease intervertebral disc degeneration in rats.

    “Further in vivo experiments revealed that Adipo-sEV-mediated delivery of NAMPT attenuated IVDD in rats by rejuvenating senescent NPCs and EPCs.”

    Animalsin vivo

    Small Extracellular Vesicles Derived from Adipocytes Attenuate Intervertebral Disc Degeneration in Rats by Rejuvenating Senescent Nucleus Pulposus Cells and Endplate Cells by Delivering Exogenous NAMPT

    Oxidative medicine and cellular longevity14 Aug 2021

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