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Adenovirus type 12 E1B 54k protein

Adenovirus type 12 E1B 54k protein has been studied in 1 paper since 1997: none in people yet, 1 in cells. No study of it in people or animals has been published yet. The newest paper, Sep 1, 1997: “Adenovirus type 12 early region 1B 54K protein significantly extends the life span of normal mammalian cells in culture”.

Intervention

1 paper studies it2 findingsUpdated

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Cells1

What did studies of Adenovirus type 12 E1B 54k protein find?

2

Studies of Adenovirus type 12 E1B 54k protein measured 2 outcomes; the most studied are cellular senescence (1 study) and lifespan (1).

Cellular senescence

downin human cells1

1 study

  1. Adenovirus type 12 E1B 54k protein inhibits cellular senescence in human cells.

    “These 54K+ cells escape the normal senescence checkpoint (M1) and show a very extended secondary growth phase.”

    Cells54K+ cells

    Adenovirus type 12 early region 1B 54K protein significantly extends the life span of normal mammalian cells in culture

    Journal of virology

More on Cellular senescence

Lifespan

upin human cells1

1 study

  1. Adenovirus type 12 E1B 54k protein extends lifespan in human cells (two to four total life spans).

    “The life span of normal human cells in culture is extended by two to four total life spans following retrovirus-mediated transfer of the adenovirus type 12 E1B 54,000-molecular-weight protein”

    Cellsretrovirus-mediated transfer

    Adenovirus type 12 early region 1B 54K protein significantly extends the life span of normal mammalian cells in culture

    Journal of virology

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