Activity engagement

5 papers5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

4 independent labs in 3 countries

Funder: Ningxia Medical University

Humans5

Outcomes

Cognitive decline

downin humans1

1 study

Activity engagement protects against cognitive decline in humans (p < 0.05).
“Crucially, activity engagement is associated with a weaker impact of frailty on cognitive abilities, with greater involvement linked to less pronounced cognitive decline.”
Humansn = 4,652
Association between spouse health and cognitive function in older Chinese adults: a moderated mediation of frailty and activity engagement
BMC geriatrics25 Nov 2025

Spatial working memory

no changein humans1

1 study

Activity engagement has no effect on spatial working memory in humans.
“activity engagement did not have short-term effects on processing speed and spatial working memory”
Humans
SHORT-TERM ASSOCIATIONS OF ACTIVITY ENGAGEMENT WITH COGNITIVE PERFORMANCE
GSA 2024 abstract31 Dec 2024

Processing speed

no changein humans1

1 study

Activity engagement has no effect on processing speed in humans.
“activity engagement did not have short-term effects on processing speed and spatial working memory”
Humans
SHORT-TERM ASSOCIATIONS OF ACTIVITY ENGAGEMENT WITH COGNITIVE PERFORMANCE
GSA 2024 abstract31 Dec 2024

Associations

Busyness

upin humans1

1 study

Busyness is associated with activity engagement in humans (rs=.20).
“Busyness was weakly correlated with activity variety and frequency (rs=.20)”
Humansn = 206
BUSYNESS MAY NOT MATTER: ASSOCIATIONS BETWEEN BUSYNESS, ACTIVITY ENGAGEMENT, AND COGNITION
GSA 2024 abstract31 Dec 2024