Activated protein C
Activated protein C has been studied in 3 papers since 2022: none in people yet, 3 in animals. The research so far is in animals. The newest paper, Aug 15, 2025: “Activated Protein C Suppresses Cardiomyocyte Senescence in Diabetic Cardiomyopathy via PAR1/PAR3-P85-CaMKIIδ Axis”.
3 papers study it4 findingsUpdated
- 2 independent labs in 2 countries
- Funders: National Natural Science Foundation of China and 1 more
- Animals3
What did studies of Activated protein C find?
3Studies of Activated protein C measured 3 outcomes; the most studied are cellular senescence (1 study), cardiac function (1) and vascular endothelial cell barrier disruption (1).
Cellular senescence
downin mice1downin rat cells1
1 study
Cellular senescence
downin mice1downin rat cells1
Activated protein C decreases cellular senescence in rat cells.
“The antisenescence role of aPC was reaffirmed by PC treatment in vivo and aPC intervention in cultured neonatal rat ventricular myocytes in vitro.”
Cellsin cultured neonatal rat ventricular myocytesheart
Diabetes
Activated protein C decreases cellular senescence in mice.
“The antisenescence role of aPC was reaffirmed by PC treatment in vivo and aPC intervention in cultured neonatal rat ventricular myocytes in vitro.”
Animalsin diabetic mice
Diabetes
Cardiac function
upin mice1
1 study
Cardiac function
upin mice1
Activated protein C improves cardiac function in mice.
“investigated the protective effects of aPC on DbCM through intraperitoneal injection of PC.”
Animalsin diabetic cardiomyopathy
Diabetes
Vascular endothelial cell barrier disruption
downin mouse cells1
1 study
Vascular endothelial cell barrier disruption
downin mouse cells1
Activated protein C prevents vascular endothelial cell barrier disruption in mouse cells.
“Activated protein C pretreatment maintained barrier permeability and prevented glucose-induced expression of senescence and UPR markers in vitro.”
Cellsglucose-induced in vitro
Nutrients