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Acetyl-l-carnitine + alpha-lipoic acid + nicotinamide

Intervention

1 paper4 findings

PubChem 7045767PubChem 864PubChem 936ChEBI 57589ChEBI 16494ChEBI 17154

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Animals1

Outcomes

4

Hemostatic abnormalities

downin rats1

1 study

  1. Acetyl-l-carnitine + alpha-lipoic acid + nicotinamide decreases hemostatic abnormalities in rats (Partial correction).

    “partially corrected the hemostatic abnormalities.”

    Animalshigh-calorie diet- and streptozotocin-induced type 2 diabetesacetyl-L-carnitine 100 mg/kg; alpha-lipoic acid 50 mg/kg; nicotinamide 100 mg/kg2 weeksmales

    Mitochondria-targeting compounds for management of metabolic and hemostatic abnormalities associated with heart dysfunctions in experimental type 2 diabetes

    Endocrine regulations1 Jan 2025

NAD+ metabolism

upin rats1

1 study

  1. Acetyl-l-carnitine + alpha-lipoic acid + nicotinamide improves NAD+ metabolism in rats.

    “partially restored the cardiac NAD+ metabolism”

    Animalshigh-calorie diet- and streptozotocin-induced type 2 diabetesheartacetyl-L-carnitine 100 mg/kg; alpha-lipoic acid 50 mg/kg; nicotinamide 100 mg/kg2 weeksmales

    Mitochondria-targeting compounds for management of metabolic and hemostatic abnormalities associated with heart dysfunctions in experimental type 2 diabetes

    Endocrine regulations1 Jan 2025

More on NAD+ metabolism

HbA1c

downin rats1

1 study

  1. Acetyl-l-carnitine + alpha-lipoic acid + nicotinamide decreases HbA1c in rats (1.7-fold reduction).

    “Combined treatment lowered the glucose levels by 1.3-fold and HbA1c by 1.7-fold”

    Animalshigh-calorie diet- and streptozotocin-induced type 2 diabetesbloodacetyl-L-carnitine 100 mg/kg; alpha-lipoic acid 50 mg/kg; nicotinamide 100 mg/kg2 weeksmales

    Mitochondria-targeting compounds for management of metabolic and hemostatic abnormalities associated with heart dysfunctions in experimental type 2 diabetes

    Endocrine regulations1 Jan 2025

More on HbA1c

Fasting blood glucose

downin rats1

1 study

  1. Acetyl-l-carnitine + alpha-lipoic acid + nicotinamide decreases fasting blood glucose in rats (1.3-fold reduction).

    “Combined treatment lowered the glucose levels by 1.3-fold and HbA1c by 1.7-fold”

    Animalshigh-calorie diet- and streptozotocin-induced type 2 diabetesbloodacetyl-L-carnitine 100 mg/kg; alpha-lipoic acid 50 mg/kg; nicotinamide 100 mg/kg2 weeksmales

    Mitochondria-targeting compounds for management of metabolic and hemostatic abnormalities associated with heart dysfunctions in experimental type 2 diabetes

    Endocrine regulations1 Jan 2025

More on Fasting blood glucose

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