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Aav-shsmox

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and 1 more
  • Animals1

Outcomes

3

Mitochondrial function

downin mice1

1 study

  1. Aav-shsmox impairs mitochondrial function in mice.

    “AAV-shSmox adult mice decreased running distance, speed and time, myofibre CSA alongside mitochondrial function, compared with controls.”

    AnimalsAAV-shSmox-induced Smox knockdowntibialis anterior

    A Novel Research Paradigm for Sarcopenia of Limb Muscles: Lessons From the Perpetually Working Diaphragm's Anti-Aging Mechanisms

    Journal of cachexia, sarcopenia and muscleApr 1, 2025

Myofibre cross-sectional area

downin mice1

1 study

  1. Aav-shsmox decreases myofibre cross-sectional area in mice.

    “AAV-shSmox adult mice decreased running distance, speed and time, myofibre CSA alongside mitochondrial function, compared with controls.”

    AnimalsAAV-shSmox-induced Smox knockdowntibialis anterior

    A Novel Research Paradigm for Sarcopenia of Limb Muscles: Lessons From the Perpetually Working Diaphragm's Anti-Aging Mechanisms

    Journal of cachexia, sarcopenia and muscleApr 1, 2025

Running distance

downin mice1

1 study

  1. Aav-shsmox decreases running distance in mice.

    “AAV-shSmox adult mice decreased running distance, speed and time, myofibre CSA alongside mitochondrial function, compared with controls.”

    AnimalsAAV-shSmox-induced Smox knockdowntibialis anterior

    A Novel Research Paradigm for Sarcopenia of Limb Muscles: Lessons From the Perpetually Working Diaphragm's Anti-Aging Mechanisms

    Journal of cachexia, sarcopenia and muscleApr 1, 2025

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