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Aav(php.eb)-gfap-hsod2

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Institute of General Medical Sciences and 1 more
  • Animals1

Outcomes

3

Inflammation

downin mice1

1 study

  1. Aav(php.eb)-gfap-hsod2 decreases inflammation in mice.

    “aSOD2OE was associated with reductions in markers of cellular senescence and reactive astrogliosis within the hippocampus.”

    Animalshippocampusmales

    Enhancing Mitochondrial Matrix Antioxidant SOD2 in Astrocytes Mitigates Cellular Senescence and Cognitive Impairment in Aging

    Aging and disease9 Oct 2025

More on Inflammation

Cellular senescence

downin mice1

1 study

  1. Aav(php.eb)-gfap-hsod2 decreases cellular senescence in mice.

    “aSOD2OE was associated with reductions in markers of cellular senescence and reactive astrogliosis within the hippocampus.”

    Animalshippocampusmales

    Enhancing Mitochondrial Matrix Antioxidant SOD2 in Astrocytes Mitigates Cellular Senescence and Cognitive Impairment in Aging

    Aging and disease9 Oct 2025

More on Cellular senescence

Spatial working memory

upin mice1

1 study

  1. Aav(php.eb)-gfap-hsod2 improves spatial working memory in mice.

    “aSOD2OE significantly improved spatial working memory performance compared to aged GFP controls.”

    Animalshippocampusmales

    Enhancing Mitochondrial Matrix Antioxidant SOD2 in Astrocytes Mitigates Cellular Senescence and Cognitive Impairment in Aging

    Aging and disease9 Oct 2025

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