6-ppd
- 1 lab in 1 country
- Funders: Korea Institute of Toxicology and 3 more
- Model organisms1
Outcomes
3Apoptosis
upin mouse cells1
1 study
Apoptosis
upin mouse cells1
6-ppd induces apoptosis in mouse cells.
“In MEFs, 6-PPD caused dose-dependent increases in cell death, apoptosis, and mitochondrial dysfunction, along with elevated reactive oxygen species (ROS).”
Cells
Journal of hazardous materials31 Oct 2025
Mobility
downin worms1
1 study
Mobility
downin worms1
6-ppd impairs mobility in worms.
“Mitochondrial impairment, increased ROS, decreased mobility, and weakened stress tolerance were also observed.”
Model organisms
Journal of hazardous materials31 Oct 2025
Lifespan
downin worms1
1 study
Lifespan
downin worms1
6-ppd shortens lifespan in worms.
“In C. elegans, 6-PPD exposure led to higher mortality, delayed development, reduced reproduction, and shortened lifespan.”
Model organisms
Journal of hazardous materials31 Oct 2025
Latest
1 in 12 monthsJournal of Environmental Sciences
Simultaneously PYCR-1 and ALH-6 inhibition exacerbates 6-PPD quinone toxicity via disrupting proline and glutamate metabolisms and activating insulin signals in Caenorhabditis elegans
Experiments in wormsAmino acid metabolism
Journal of Hazardous Materials
6-PPD induces mitochondrial dysfunction and reduces healthspan and lifespan through SKN-1 in Caenorhabditis elegans
Experiments in wormsskn-1
Journal of Environmental Sciences
6-PPD quinone reduces lifespan by activating a feedback loop between cholesterol transformation related signal and insulin signaling in Caenorhabditis elegans
Experiments in wormsFOXO signalling