6-ppd

Intervention

1 paper3 findings

PubChem 13101

  • 1 lab in 1 country
  • Funders: Korea Institute of Toxicology and 3 more
  • Model organisms1

Outcomes

3

Apoptosis

upin mouse cells1

1 study
  1. 6-ppd induces apoptosis in mouse cells.

    “In MEFs, 6-PPD caused dose-dependent increases in cell death, apoptosis, and mitochondrial dysfunction, along with elevated reactive oxygen species (ROS).”

    Cells

    6-PPD induces mitochondrial dysfunction and reduces healthspan and lifespan through SKN-1 in Caenorhabditis elegans

    Journal of hazardous materials31 Oct 2025

More on Apoptosis

Mobility

downin worms1

1 study
  1. 6-ppd impairs mobility in worms.

    “Mitochondrial impairment, increased ROS, decreased mobility, and weakened stress tolerance were also observed.”

    Model organisms

    6-PPD induces mitochondrial dysfunction and reduces healthspan and lifespan through SKN-1 in Caenorhabditis elegans

    Journal of hazardous materials31 Oct 2025

Lifespan

downin worms1

1 study
  1. 6-ppd shortens lifespan in worms.

    “In C. elegans, 6-PPD exposure led to higher mortality, delayed development, reduced reproduction, and shortened lifespan.”

    Model organisms

    6-PPD induces mitochondrial dysfunction and reduces healthspan and lifespan through SKN-1 in Caenorhabditis elegans

    Journal of hazardous materials31 Oct 2025

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