5-(2-nitroethenyl)salicylic acid

2 papers1 finding

1 lab

Cells1

Outcomes

1

AKR1B1

downin human cells1

1 study

5-(2-nitroethenyl)salicylic acid inhibits AKR1B1 in human cells (IC50 of 14.3 ± 1.6 μg).
“5-(2-nitroethenyl)salicylic acid (5-SANA) is demonstrated to be a potent, isoform-selective inhibitor of human ALR2, with an IC50 of 14.3 ± 1.6 μg”
Cells
Therapeutic Resumption of Incretin Efficacy via Upstream ALR2–RAGE Axis Reversal: Structural and Mechanistic Insights into 5-SANA Co-Administration
Zenodo (CERN European Organization for Nuclear Research)Jun 10, 2026Preprint

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The GLP-1 Plateau Problem: Why Upstream Aldose Reductase 2 Inhibition Is the Missing Pharmacological Partner for Every Incretin-Based Obesity Therapy

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