Amyloid-β1–42

1. Liraglutide decreases amyloid-β1–42 in mice.

   “Despite the limited signs of cognitive changes in mature female mice, liraglutide only reduced their cortical Aβ1−42 levels.”

   Animals3xTg-AD micecerebral cortex0.2 mg/kg, once/day28 daysfemales

   Liraglutide Protects Against Brain Amyloid-β₁₋₄₂ Accumulation in Female Mice with Early Alzheimer's Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative Stress and Inflammation

   International journal of molecular sciences·4 Mar 2020

More on Liraglutide

1. 3,3-dimethyl-1-butanol decreases amyloid-β1–42 in mice.

   “DMB treatment also induced a decrease in the Amyloid-β (Aβ)1−42, β-secretase, and β-secretase-cleaved C-terminal fragment (βCTF) levels in the hippocampus.”

   AnimalsAPP/PS1 micehippocampus

   Decreased levels of circulating trimethylamine N-oxide alleviate cognitive and pathological deterioration in transgenic mice: a potential therapeutic approach for Alzheimer's disease

   Aging·14 Oct 2019

More on 3,3-dimethyl-1-butanol