2-mercaptoethanol
- 4 independent labs in 3 countries
- Funders: National Cancer Institute and 2 more
- Animals4
- Cells1
Outcomes
9Age-related behavioural deficits
no changein mice1no changein rats1
1 study
Age-related behavioural deficits
no changein mice1no changein rats1
2-mercaptoethanol has no effect on age-related behavioural deficits in rats.
“Age-related behavioural deficits, such as locomotor activity, habituation performance and learning ability, do not reflect any effect of 2-ME long-term treatment.”
Animalsmonths
Biomedica biochimica acta1 Jan 1990
2-mercaptoethanol has no effect on age-related behavioural deficits in mice.
“Age-related behavioural deficits, such as locomotor activity, habituation performance and learning ability, do not reflect any effect of 2-ME long-term treatment.”
Animalsmonths
Biomedica biochimica acta1 Jan 1990
Posthypoxic dopamine release inhibition
downin mice1downin rats1
1 study
Posthypoxic dopamine release inhibition
downin mice1downin rats1
2-mercaptoethanol prevents posthypoxic dopamine release inhibition in rats.
“Posthypoxic release inhibition is prevented by a 2-ME pretreatment for 3 weeks but not by an acute single application even at high dosages.”
AnimalsPretreatment before hypoxia exposurebrain slices3 weeks
Biomedica biochimica acta1 Jan 1990
2-mercaptoethanol prevents posthypoxic dopamine release inhibition in mice.
“Posthypoxic release inhibition is prevented by a 2-ME pretreatment for 3 weeks but not by an acute single application even at high dosages.”
AnimalsPretreatment before hypoxia exposurebrain slices3 weeks
Biomedica biochimica acta1 Jan 1990
Dopamine release
upin mice1upin rats1
1 study
Dopamine release
upin mice1upin rats1
2-mercaptoethanol increases dopamine release in rats.
“Long-term 2-ME treatment for months abolishes the age-related decrease of transmitter release and prevents changes in malondialdehyde formation.”
AnimalsPrevention of age-related release declinebrain slicesmonths
Biomedica biochimica acta1 Jan 1990
2-mercaptoethanol increases dopamine release in mice.
“Long-term 2-ME treatment for months abolishes the age-related decrease of transmitter release and prevents changes in malondialdehyde formation.”
AnimalsPrevention of age-related release declinebrain slicesmonths
Biomedica biochimica acta1 Jan 1990
Mammary tumors
downin mice1
1 study
Mammary tumors
downin mice1
2-mercaptoethanol prevents mammary tumors in mice.
“The only tumors detected were mammary and only in animals that were both exposed to radiation and not treated with 2-ME.”
Animalsin mice exposed to sublethal ionizing gamma-rays
Journal of cancer research and therapeutics1 Jan 2014
Malondialdehyde
upin mice1
1 study
Malondialdehyde
upin mice1
2-mercaptoethanol increases malondialdehyde in mice.
“malondialdehyde concentrations in the livers of the experimental mice were significantly increased.”
Animalsin physiological salineliver4 microgramslong-termmales
Effect of 2-mercaptoethanol on some metabolic indices of ageing of CBA/Ca inbred mice
Mechanisms of ageing and development1 Oct 1988
Total body protein turnover biological half-life
downin mice1
1 study
Total body protein turnover biological half-life
downin mice1
2-mercaptoethanol decreases total body protein turnover biological half-life in mice.
“After about 1 year of age the apparent biological half-life time of total body protein (T1/2) was observed to be shorter in the treated mice.”
Animalsin physiological saline4 microgramslong-termmales
Effect of 2-mercaptoethanol on some metabolic indices of ageing of CBA/Ca inbred mice
Mechanisms of ageing and development1 Oct 1988
Heat performance capacity
upin mice1
1 study
Heat performance capacity
upin mice1
2-mercaptoethanol improves heat performance capacity in mice.
“in the oldest group, heat performance capacity was better than those of the controls.”
Animalsin physiological saline4 microgramslong-termmales
Effect of 2-mercaptoethanol on some metabolic indices of ageing of CBA/Ca inbred mice
Mechanisms of ageing and development1 Oct 1988
Immune response
upin mice1
1 study
Immune response
upin mice1
2-mercaptoethanol improves immune response in mice.
“T-cell-dependent immune responses were higher in the 2-ME-fed mice compared to the controls when the animals were young”
Animalsdietary supplementationspleen
Mechanisms of ageing and development31 Oct 1984
Lifespan
upin mice1
1 study
Lifespan
upin mice1
2-mercaptoethanol extends lifespan in mice.
“animals fed the 2-ME diet had an increased mean and maximum life span”
Animalsdietary supplementation
Mechanisms of ageing and development31 Oct 1984
Associations
2Dunn-sarcomas associated with amyloidoses
downin mice1
1 study
Dunn-sarcomas associated with amyloidoses
downin mice1
2-mercaptoethanol lowers the risk of Dunn-sarcomas associated with amyloidoses in mice.
“Autopsy data showed that Dunn-sarcomas associated with amyloidoses occurred more frequently in the untreated mice.”
Animalsin physiological saline4 microgramslong-termmales
Effect of 2-mercaptoethanol on some metabolic indices of ageing of CBA/Ca inbred mice
Mechanisms of ageing and development1 Oct 1988
Cancer
downin mice1
1 study
Cancer
downin mice1
2-mercaptoethanol lowers the risk of cancer in mice.
“postponed onset and decreased incidence of tumors”
Animalsdietary supplementation
Mechanisms of ageing and development31 Oct 1984