WWC1

1. WWC1 is linked with higher gray matter volume in humans (CC or CT vs. TT genotype) (P < 0.05).

   “KIBRA rs17070145 C-allele (CC or CT vs. TT genotype) was significantly associated with greater gray matter volume (GMV) mainly in the bilateral orbitofrontal cortex and left thalamus (P < 0.05)”

   HumansCC or CT vs. TT genotypebilateral orbitofrontal cortex and left thalamusn = 1,087

   Thalamic gray matter volume mediates the association between KIBRA polymorphism and olfactory function among older adults: a population-based study

   Cerebral cortex (New York, N.Y. : 1991)·Aug 17, 2022

1. WWC1 was not clearly linked with hippocampal volume in humans (WWC1 rs17070145 genotype and genotype-by-age interaction).

   “neither KIBRA nor the interaction between KIBRA and age predicted hippocampal volumes.”

   HumansWWC1 rs17070145 genotype and genotype-by-age interactionhippocampus

   Age-Modulated Associations between KIBRA, Brain Volume, and Verbal Memory among Healthy Older Adults

   Frontiers in aging neuroscience·Jan 10, 2018

1. WWC1 is associated with cognitive function in linear regression models for interaction (P < 0.03).

   “Three statistically significant interactions with two cognitive function measures -category verbal fluency and immediate story recall-were found in the Montreal study: glaucoma and AMD with rs17070145 and verbal fluency”

   Humansin linear regression models for interaction

   Does the Association Between Eye Disease and Cognitive Function Vary by Genetic Risk of Cognitive Decline? An Analysis of Hospital Data With Replication in the Canadian Longitudinal Study on Aging

   Investigative ophthalmology & visual science·Jun 2, 2025

1. WWC1 is linked with a lower risk of olfactory impairment in humans (CC or CT vs. TT genotype) (OR 0.73 (95% CI 0.56-0.95)).

   “KIBRA rs17070145 C-allele (CC or CT vs. TT genotype) was significantly associated with greater gray matter volume (GMV) mainly in the bilateral orbitofrontal cortex and left thalamus (P < 0.05) and with the multi-adjusted odds ratio of 0.73 (95% confidence interval 0.56-0.95) for OI”

   HumansCC or CT vs. TT genotypen = 1,016

   Thalamic gray matter volume mediates the association between KIBRA polymorphism and olfactory function among older adults: a population-based study

   Cerebral cortex (New York, N.Y. : 1991)·Aug 17, 2022

More on Olfactory impairment

1. WWC1 is associated with left lingual gyrus gray matter volume in humans (WWC1 rs17070145 T carriers versus CC homozygotes).

   “Focusing on the older old group, this advantage for T carriers was also evident in left lingual gyrus gray matter”

   HumansWWC1 rs17070145 T carriers versus CC homozygotesleft lingual gyrus gray mattern = 62

   Age-Modulated Associations between KIBRA, Brain Volume, and Verbal Memory among Healthy Older Adults

   Frontiers in aging neuroscience·Jan 10, 2018

1. WWC1 is associated with frontal white matter volume in humans (WWC1 rs17070145 T carriers versus CC homozygotes; advantage increased with age).

   “an advantage for T carriers in frontal white matter volume that increased with age.”

   HumansWWC1 rs17070145 T carriers versus CC homozygotes; advantage increased with agefrontal white matter

   Age-Modulated Associations between KIBRA, Brain Volume, and Verbal Memory among Healthy Older Adults

   Frontiers in aging neuroscience·Jan 10, 2018

1. WWC1 is associated with verbal memory performance in humans (WWC1 rs17070145 T carriers versus CC homozygotes; cognitively healthy adults).

   “T carriers maintained verbal memory performance with increasing age while CC homozygotes declined.”

   HumansWWC1 rs17070145 T carriers versus CC homozygotes; cognitively healthy adults

   Age-Modulated Associations between KIBRA, Brain Volume, and Verbal Memory among Healthy Older Adults

   Frontiers in aging neuroscience·Jan 10, 2018