wrn

1. wrn decreases chromosomal aberrations in human cells.

   “complementation of WS cells with WRN”

   Cellsin WS cellsfibroblasts

   Telomere dysfunction as a cause of genomic instability in Werner syndrome

   Proceedings of the National Academy of Sciences of the United States of America·6 Feb 2007

1. wrn increases proliferative capacity in mouse cells.

   “mouse embryo fibroblasts derived from homozygous WS embryos show premature loss of proliferative capacity.”

   Cellsshown by homozygous Wrn deletionembryonic fibroblast

   A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

   Proceedings of the National Academy of Sciences of the United States of America·27 Oct 1998

1. wrn decreases sensitivity to topoisomerase inhibitors in mouse cells.

   “are significantly more sensitive to topoisomerase inhibitors (especially camptothecin) than are wild-type ES cells.”

   Cellsshown by homozygous Wrn deletion; especially camptothecinembryonic stem cell

   A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

   Proceedings of the National Academy of Sciences of the United States of America·27 Oct 1998

1. wrn decreases mutation rate in mouse cells.

   “such cells display a higher mutation rate”

   Cellsshown by homozygous Wrn deletionembryonic stem cell

   A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

   Proceedings of the National Academy of Sciences of the United States of America·27 Oct 1998

More on Mutation rate

1. wrn increases embryonic survival in mice.

   “While displaying reduced embryonic survival, live-born WS mice otherwise appear normal during their first year of life.”

   Animalsshown by Wrn deletion

   A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

   Proceedings of the National Academy of Sciences of the United States of America·27 Oct 1998

1. wrn induces DNA unwinding in human cells.

   “Here we report that the WS protein does indeed catalyze DNA unwinding.”

   Cells

   The Werner syndrome protein is a DNA helicase

   Nature genetics·1 Sep 1997

1. wrn raises the risk of Werner syndrome in humans.

   “It is caused by null mutations of the WRN gene”

   Reviewnull mutations of the WRN gene

   Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventions

   Ageing research reviews·15 Mar 2016

2. wrn raises the risk of Werner syndrome in humans.

   “Mutations in the WRN gene are the causative factor of Werner syndrome (WS).”

   Reviewmutations in WRN

   Roles of Werner syndrome protein in protection of genome integrity

   DNA repair·13 Jan 2010

More on Werner syndrome

1. wrn raises the risk of cancer in humans.

   “Defects in three of the RecQ helicases, RecQ4, BLM, and WRN, cause human pathologies linked with cancer predisposition and premature aging.”

   Reviewdefects in RecQ4, BLM, and WRN

   Roles of Werner syndrome protein in protection of genome integrity

   DNA repair·13 Jan 2010

More on Cancer

1. wrn raises the risk of premature aging in humans.

   “Defects in three of the RecQ helicases, RecQ4, BLM, and WRN, cause human pathologies linked with cancer predisposition and premature aging.”

   Reviewdefects in RecQ4, BLM, and WRN

   Roles of Werner syndrome protein in protection of genome integrity

   DNA repair·13 Jan 2010

1. wrn is associated with bilateral ocular cataracts in humans.

   “Clinical data confirm that the most penetrant phenotype is bilateral ocular cataracts.”

   Humansin Werner syndrome patients

   The spectrum of WRN mutations in Werner syndrome patients

   Human mutation·1 Jun 2006

More on Bilateral ocular cataracts

1. wrn is associated with median age of death in humans (54 years).

   “The median age of death, previously reported to be in the range of 46-48 years, is 54 years.”

   Humansin Werner syndrome patients

   The spectrum of WRN mutations in Werner syndrome patients

   Human mutation·1 Jun 2006

1. TERF2 is associated with wrn in human cells.

   “WRN and TRF2 also interact directly in the absence of DNA.”

   Cells

   TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA

   Oncogene·8 Jan 2004

More on TERF2

1. wrn is associated with multiprotein DNA replication complex in mouse cells.

   “wild-type, but not mutant, WS protein copurifies through a series of centrifugation and chromatography steps with a multiprotein DNA replication complex.”

   Cellswild-type protein, but not mutant protein; copurification

   A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

   Proceedings of the National Academy of Sciences of the United States of America·27 Oct 1998