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UOX

Gene

3 papers5 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 2 countries
  • 1 finding against
  • Funders: National Natural Science Foundation of China and 3 more
  • Animals3

Effects

2

Lifespan

upin mice1downin rats1

2 studies

  1. UOX shortens lifespan in rats (~450 days vs >626 days).

    “The lifespan of KDY rats was significantly shorter than that of WT rats (more than 626 days).”

    Animalsuricase deficiency

    Uricase deficiency in rats results in a variety of metabolic disorders, addition to gouty nephropathy

    PloS oneAug 22, 2025

  2. UOX extends lifespan in mice.

    “the life span of female but not male UOX+/- mice is significantly increased compared to wild-type mice.”

    Animalsin female UOX+/- mice compared to wild-typefemales

    Uric acid enhances longevity and endurance and protects the brain against ischemia

    Neurobiology of agingDec 12, 2018

Endurance

upin mice1

1 study

  1. UOX improves endurance in mice.

    “the endurance of the UOX+/- mice is significantly greater than wild-type mice.”

    Animalsin UOX+/- mice compared to wild-type

    Uric acid enhances longevity and endurance and protects the brain against ischemia

    Neurobiology of agingDec 12, 2018

Associations

2

Hypertension

upin rats1

1 study

  1. UOX raises the risk of hypertension in rats.

    “KDY rats also showed signs of atherosclerosis and hypertension in the late stage of their lifespan.”

    Animalsuricase deficiency

    Uricase deficiency in rats results in a variety of metabolic disorders, addition to gouty nephropathy

    PloS oneAug 22, 2025

More on Hypertension

Gouty nephropathy

upin rats1

1 study

  1. UOX raises the risk of gouty nephropathy in rats.

    “Histological examination showed that gouty nephropathy appeared after approximately 45 days of age, before the rats developed medullary injury, medullary interstitial fibrosis, cortical glomerulus injury, and glomerular fibrosis.”

    Animalsuricase-deficient KDY rats

    Uricase deficiency in rats results in a variety of metabolic disorders, addition to gouty nephropathy

    PloS oneAug 22, 2025

More on Gouty nephropathy

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