Gouty nephropathy

1. UOX raises the risk of gouty nephropathy in rats.

   “Histological examination showed that gouty nephropathy appeared after approximately 45 days of age, before the rats developed medullary injury, medullary interstitial fibrosis, cortical glomerulus injury, and glomerular fibrosis.”

   Animalsuricase-deficient KDY rats

   Uricase deficiency in rats results in a variety of metabolic disorders, addition to gouty nephropathy

   PloS one·Aug 22, 2025

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