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unc-68

Gene

1 paper1 finding

NCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Heart, Lung, and Blood Institute and 4 more
  • Model organisms1

Effects

1

Muscle function

downin worms1

1 study

  1. unc-68 impairs muscle function in worms.

    “UNC-68 is oxidized and depleted of FKB-2 in an age-dependent manner, resulting in 'leaky' channels, depleted SR Ca2+ stores, reduced body wall muscle Ca2+ transients, and age-dependent muscle weakness.”

    Model organismsaging

    Role of oxidation of excitation-contraction coupling machinery in age-dependent loss of muscle function in Caenorhabditis elegans

    eLife4 May 2022

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