unc-104

unc-104 improves associative learning and memory in worms.

“UNC-104-overexpressing animals outperform wild-type controls in associative learning and memory tests.”

Model organismsUNC-104 overexpression compared with wild-type controls

The Neuronal Kinesin UNC-104/KIF1A Is a Key Regulator of Synaptic Aging and Insulin Signaling-Regulated Memory

Current biology : CB·Feb 11, 2016

unc-104 extends lifespan in worms (Mild extension).

“upregulation of UNC-104 significantly improves motor function at advanced ages and also mildly extends lifespan.”

Model organismsUNC-104 upregulation

The Neuronal Kinesin UNC-104/KIF1A Is a Key Regulator of Synaptic Aging and Insulin Signaling-Regulated Memory

Current biology : CB·Feb 11, 2016

unc-104 improves motor function in worms.

“upregulation of UNC-104 significantly improves motor function at advanced ages”

Model organismsUNC-104 upregulation

The Neuronal Kinesin UNC-104/KIF1A Is a Key Regulator of Synaptic Aging and Insulin Signaling-Regulated Memory

Current biology : CB·Feb 11, 2016

unc-104 is associated with lifespan in worms.

“Both fbxb-65 and UNC-104, independently of FBXB-65, regulate axonal pre-SV distribution, transport of pre-SVs at branch points and organismal lifespan.”

Model organisms

F-box protein FBXB-65 regulates anterograde transport of the kinesin-3 motor UNC-104 through a PTM near its cargo-binding PH domain

Journal of cell science·Mar 13, 2024