TTYH3

1. TTYH3 decreases lysosomal storage disease-associated cellular phenotypes in cells.

   “Notably, TTYH3 expression mitigates cellular phenotypes associated with lysosomal storage diseases caused by deficiencies in another lysosomal chloride channel CLN7.”

   CellsCLN7 deficiency

   TTYH3 regulates a lysosomal chloride conductance and controls lysosomal fusion, autophagy and senescence

   Cell reports·18 Jul 2026

1. TTYH3 decreases cellular senescence in cells.

   “Moreover, TTYH3 enhances autophagy by inhibiting the AKT/mTOR signaling pathway and alleviates cellular senescence via activation of the ERK pathway.”

   Cellsvia activation of the ERK pathway

   TTYH3 regulates a lysosomal chloride conductance and controls lysosomal fusion, autophagy and senescence

   Cell reports·18 Jul 2026

More on Cellular senescence

1. TTYH3 increases autophagy in cells.

   “Moreover, TTYH3 enhances autophagy by inhibiting the AKT/mTOR signaling pathway and alleviates cellular senescence via activation of the ERK pathway.”

   Cellsvia inhibition of AKT/mTOR signaling

   TTYH3 regulates a lysosomal chloride conductance and controls lysosomal fusion, autophagy and senescence

   Cell reports·18 Jul 2026

More on Autophagy

1. TTYH3 increases lysosomal fusion in cells.

   “Overexpression of TTYH3 results in markedly enlarged lysosomes by promoting lysosomal fusion via the Ca2+/CaM and HSP90 pathways.”

   CellsTTYH3 overexpression

   TTYH3 regulates a lysosomal chloride conductance and controls lysosomal fusion, autophagy and senescence

   Cell reports·18 Jul 2026

1. TTYH3 increases lysosomal calcium release in cells.

   “TTYH3 mediates chloride efflux from the lysosomal lumen and enhances TRPML1-mediated lysosomal calcium release.”

   CellsTRPML1-mediated release

   TTYH3 regulates a lysosomal chloride conductance and controls lysosomal fusion, autophagy and senescence

   Cell reports·18 Jul 2026

1. TTYH3 mediates lysosomal chloride efflux in cells.

   “TTYH3 mediates chloride efflux from the lysosomal lumen and enhances TRPML1-mediated lysosomal calcium release.”

   Cells

   TTYH3 regulates a lysosomal chloride conductance and controls lysosomal fusion, autophagy and senescence

   Cell reports·18 Jul 2026