Top3beta

1. Top3beta decreases neurodegenerative disease in flies.

   “enzymatic activity of Top3β reduces the neurodegeneration caused by the cytotoxic human (G4C2)49 RNA”

   Model organismsin vivo test in flies expressing cytotoxic human (G4C2)49 RNA

   Drosophila Topoisomerase 3β binds to mRNAs in vivo, contributes to their localization and stability, and counteracts premature aging

   PloS one·11 Feb 2025

More on Neurodegenerative disease

1. Top3beta prevents premature aging in flies.

   “to prevent premature loss of coordinated movement and aging”

   Model organismsmutant vs wild-type

   Drosophila Topoisomerase 3β binds to mRNAs in vivo, contributes to their localization and stability, and counteracts premature aging

   PloS one·11 Feb 2025

1. Top3beta improves coordinated movement in flies.

   “to prevent premature loss of coordinated movement and aging”

   Model organismsmutant vs wild-type

   Drosophila Topoisomerase 3β binds to mRNAs in vivo, contributes to their localization and stability, and counteracts premature aging

   PloS one·11 Feb 2025

1. Top3beta improves neuromuscular junction morphology in flies.

   “Top3β is not essential for development to the adult stage but to maintain the morphology of the adult neuromuscular junction”

   Model organismsmutant vs wild-type

   Drosophila Topoisomerase 3β binds to mRNAs in vivo, contributes to their localization and stability, and counteracts premature aging

   PloS one·11 Feb 2025