TNFAIP8L2

1. TNFAIP8L2 decreases total retinal thickness in mice.

   “TIPE2-/- mice also exhibited reduced total retinal thickness”

   AnimalsTIPE2 knockoutretina

   Age-related alterations in retinal structure and blood perfusion in TIPE2 gene-knockout mice

   Experimental eye research·29 Dec 2025

1. TNFAIP8L2 decreases superficial vascular plexus perfusion in mice.

   “Genotype showed a significant main effect on superficial vascular plexus (Svp) perfusion, indicating overall lower Svp perfusion in TIPE2-/- mice”

   AnimalsTIPE2 knockoutretina

   Age-related alterations in retinal structure and blood perfusion in TIPE2 gene-knockout mice

   Experimental eye research·29 Dec 2025

1. TNFAIP8L2 inhibits oxidative stress and ROS signalling in mice.

   “Tnfaip8l2 deficiency led to features of oxidative stress in cochlear HCs”

   Animalsin cochlear HCs

   TNFAIP8L2 maintains hair cell function and regulates age-related hearing loss via mTORC1 signaling

   Molecular therapy : the journal of the American Society of Gene Therapy·30 Mar 2025

More on Oxidative stress and ROS signalling

1. TNFAIP8L2 lowers the risk of age-related hearing loss in mice.

   “Tnfaip8l2 deficiency led to features of oxidative stress in cochlear HCs and age-related hearing degeneration”

   AnimalsTnfaip8l2 deficiency

   TNFAIP8L2 maintains hair cell function and regulates age-related hearing loss via mTORC1 signaling

   Molecular therapy : the journal of the American Society of Gene Therapy·30 Mar 2025

More on Age-related hearing loss