TMEM72

1. TMEM72 activates p38 MAPK signalling in human cells.

   “Further analyses revealed that TMEM72 activated the p38/MAPK signaling pathway, leading to enhanced phosphorylation of p38 and p53”

   Cellsoverexpression

   TMEM72 Inhibits the proliferation by promoting cellular senescence through the activation of the P38/MAPK signaling pathway in renal cell carcinoma

   Translational oncology·2 May 2026

More on p38 MAPK signalling

1. TMEM72 induces cellular senescence in human cells.

   “Mechanistically, TMEM72 induced G1/S cell cycle arrest and promoted cellular senescence.”

   Cellsoverexpression

   TMEM72 Inhibits the proliferation by promoting cellular senescence through the activation of the P38/MAPK signaling pathway in renal cell carcinoma

   Translational oncology·2 May 2026

More on Cellular senescence

1. TMEM72 protects against renal cell carcinoma in human cells.

   “TMEM72 overexpression suppressed RCC cell proliferation and tumor growth, whereas its silencing promoted tumor progression.”

   Cellsoverexpression

   TMEM72 Inhibits the proliferation by promoting cellular senescence through the activation of the P38/MAPK signaling pathway in renal cell carcinoma

   Translational oncology·2 May 2026

More on Renal cell carcinoma