TIMM8B

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

1 lab in 1 country

Funder: National Natural Science Foundation of China

Animals1

Effects

neuronal apoptosis

downin mice1

1 study

TIMM8B decreases neuronal apoptosis in mice.
“Timm8b overexpression effectively preserved mitochondrial ultrastructure, mitigated ischaemic damage in heterozygous OPA1-deficient mice while diminished in homozygotes, restored OPA1 dimerization, and alleviated neuronal apoptosis and infarct expansion in aged ischaemic brains.”
Animalsheterozygous OPA1 deficiency and ischaemic strokebrain
Decreased OPA1 expression increases neuronal vulnerability to ischaemic stroke during ageing: Role of Timm8b as a therapeutic target
Free radical biology & medicine8 Dec 2025

Infarct expansion

downin mice1

1 study

TIMM8B decreases infarct expansion in mice.
“Timm8b overexpression effectively preserved mitochondrial ultrastructure, mitigated ischaemic damage in heterozygous OPA1-deficient mice while diminished in homozygotes, restored OPA1 dimerization, and alleviated neuronal apoptosis and infarct expansion in aged ischaemic brains.”
Animalsheterozygous OPA1 deficiency and ischaemic strokebrain
Decreased OPA1 expression increases neuronal vulnerability to ischaemic stroke during ageing: Role of Timm8b as a therapeutic target
Free radical biology & medicine8 Dec 2025

Latest

1 in 12 months

Free Radical Biology & Medicine11 Dec

Decreased OPA1 expression increases neuronal vulnerability to ischaemic stroke during ageing: Role of Timm8b as a therapeutic target

Experiments in miceMechanisms

Paper

TIMM8B

Effects

Latest

Decreased OPA1 expression increases neuronal vulnerability to ischaemic stroke during ageing: Role of Timm8b as a therapeutic target

Related