AgingResearch.NewsJoin free

TIMELESS

Gene

7 papers study it7 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

Includes the processes named after it and trials of drugs aimed at it.

  • 3 independent labs in 1 country
  • Funders: National Cancer Institute and 2 more
  • 1 of 7 findings with company ties
  • Animals1
  • Model organisms1
  • Cells4

Effects

3

Cellular senescence

downin cells1downin human cells1

2 studies

  1. TIMELESS inhibits cellular senescence in human cells.

    “ectopic expression of TIM delays the induction of OIS via enhancing protection of stalled forks”

    Cellsectopic expression of TIM in cells undergoing OIS

    Loss of DNA replication fork protection by TIMELESS degradation supports oncogene-induced senescence

    Biochemical and biophysical research communicationsJun 12, 2025

  2. TIMELESS prevents cellular senescence in human cells.

    “Loss of TIM is sufficient to induce senescence”

    Cellsloss of TIM

    Loss of DNA replication fork protection by TIMELESS degradation supports oncogene-induced senescence

    Biochemical and biophysical research communicationsJun 12, 2025

  3. TIMELESS inhibits cellular senescence in cells.

    “Knockdown of TIMELESS accelerated cellular senescence induced by ectopic expression of RasV12, and overexpression of TIMELESS delayed this kind onset of senescence.”

    CellsRasV12-induced senescence; shown by TIMELESS knockdown and overexpression

    Loss of circadian protein TIMELESS accelerates the progression of cellular senescence

    Biochemical and biophysical research communicationsAug 9, 2018

More on Cellular senescence

Lifespan

downin flies1

1 study

  1. TIMELESS shortens lifespan in flies.

    “Flies with the timeless gene mutation (tim01) have a significantly shorter lifespan than controls.”

    Model organismstim01 mutation

    Dozing Off With Drosophila: The Effect of Disrupted Circadian Rhythms and Sleep Disturbance on Mortality, Mood, and Addiction

    Neuroscience insightsDec 24, 2023

Genomic instability

downin cells1

1 study

  1. TIMELESS decreases genomic instability in cells.

    “micrococcal nuclease assays proved depletion of TIMELESS exacerbated genomic instability at the onset of senescence.”

    Cellsat the onset of senescence; shown by TIMELESS depletion

    Loss of circadian protein TIMELESS accelerates the progression of cellular senescence

    Biochemical and biophysical research communicationsAug 9, 2018

Upstream

2

PARP1

downin human cells1

1 study

  1. PARP1 decreases TIMELESS in human cells.

    “HRASG12V expression induces cellular poly(ADP-ribosyl)ation mediated by PARP1, which prompts poly(ADP-ribose)/PAR-dependent TIM degradation”

    CellsHRASG12V expression

    Loss of DNA replication fork protection by TIMELESS degradation supports oncogene-induced senescence

    Biochemical and biophysical research communicationsJun 12, 2025

More on PARP1

HRAS

downin human cells1

1 study

  1. HRAS decreases TIMELESS in human cells.

    “TIMELESS (TIM), an essential regulatory component of the fork protection complex that supports the integrity of the replisome, is downregulated in non-transformed human cell lines that undergo OIS by HRASG12V expression”

    CellsHRASG12V expression

    Loss of DNA replication fork protection by TIMELESS degradation supports oncogene-induced senescence

    Biochemical and biophysical research communicationsJun 12, 2025

More on HRAS

Latest

Related