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SV40LARGE-TANTIGEN

Gene

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funder: Erasmus+
  • 2 of 2 findings with company ties
  • Cells1

Effects

2

Tumor formation

no changein mice1

1 study

  1. SV40LARGE-TANTIGEN has no effect on tumor formation in mice.

    “Neither Tag+ nor Tag- cells formed tumor in this xenotransplantation model.”

    Animalsxenotransplantation into regenerating muscle of SCID/bg immunodeficient mice

    Reversible immortalization of human myogenic cells by site-specific excision of a retrovirally transferred oncogene

    Human gene therapy1 Jul 1999

More on Tumor formation

Replicative lifespan

upin human cells1

1 study

  1. SV40LARGE-TANTIGEN extends replicative lifespan in human cells.

    “Clonal isolates of Tag-positive cells showed modified growth characteristics and a significantly extended life span, while maintaining a full myogenic potential.”

    Cellsin cultureLTTN-LoxP provirus

    Reversible immortalization of human myogenic cells by site-specific excision of a retrovirally transferred oncogene

    Human gene therapy1 Jul 1999

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