SUR2
- 1 lab in 1 country
- Funders: National Natural Science Foundation of China and 2 more
- Cells1
Effects
3Lifespan
upin yeast cells1
1 study
Lifespan
upin yeast cells1
SUR2 extends lifespan in yeast cells.
“This ceramide profile alteration impairs both mitochondrial morphology and function, ultimately shortening the chronological lifespan.”
CellsChronological lifespan; shown by loss of SUR2 function
Biochimica et biophysica acta. Molecular and cell biology of lipids22 Dec 2024
Mitochondrial morphology and function
upin yeast cells1
1 study
Mitochondrial morphology and function
upin yeast cells1
SUR2 improves mitochondrial morphology and function in yeast cells.
“This ceramide profile alteration impairs both mitochondrial morphology and function, ultimately shortening the chronological lifespan.”
CellsShown by ceramide profile alteration following loss of SUR2 function
Biochimica et biophysica acta. Molecular and cell biology of lipids22 Dec 2024
Total ceramide content
upin yeast cells1
1 study
Total ceramide content
upin yeast cells1
SUR2 increases total ceramide content in yeast cells (SUR2 loss reduced total ceramide content to about half of wild-type).
“resulting in a significant reduction of total ceramide content to about half of that in wild-type cells.”
CellsShown by loss of SUR2 function versus wild-type cells
Biochimica et biophysica acta. Molecular and cell biology of lipids22 Dec 2024