SUOX

1. CD38 decreases SUOX in mice.

   “CD38 suppressed SUOX”

   Animalsin endothelial cellsendothelium

   LATS1/2-CD38 Metabolic Rewiring Links Senescence to Intraplaque Thrombosis

   Circulation research·27 May 2026

2. CD38 inhibits SUOX in mice.

   “Mechanistically, CD38 upregulation was found to suppress SUOX expression, induce the reverse mode of mitochondrial complex V, and increase succinate dehydrogenase (SDH) activity along with ATP consumption.”

   Animalsendothelial cell-specific knockout

   Downregulation of LATS1/2 Drives Endothelial Senescence-Associated Stemness (SAS) and Atherothrombotic Lesion Formation

   bioRxiv : the preprint server for biology·21 Jun 2025Preprint

More on CD38