LATS2

3 papers2 findings

HGNC NCBI Gene Taxon

1 lab in 1 country

Funders: American Heart Association and 6 more

Humans1
Animals2

Effects

1

Atherothrombosis

downin mice2

2 studies

LATS2 decreases atherothrombosis in mice.
“Lats1het(±)/Lats2 homo(-/-)-EC-specific knockout mice survived and developed spontaneous atherothrombotic plaques with neovascularization.”
Animalsin Lats1het/Lats2 homo EC-specific knockout miceendothelium
LATS1/2-CD38 Metabolic Rewiring Links Senescence to Intraplaque Thrombosis
Circulation research27 May 2026
LATS2 decreases atherothrombosis in mice.
“Lats1 het(+ /- ) / Lats2 homo( -/- ) -EKO mice survived and developed atherothrombotic plaques exhibiting neovascularization even without further additional dietary or genetic intervention.”
Animalsendothelial cell-specific knockout
Downregulation of LATS1/2 Drives Endothelial Senescence-Associated Stemness (SAS) and Atherothrombotic Lesion Formation
bioRxiv : the preprint server for biology21 Jun 2025Preprint

More on Atherothrombosis

Latest

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Circulation Research27 May

LATS1/2-CD38 Metabolic Rewiring Links Senescence to Intraplaque Thrombosis

Experiments in miceAmino acid metabolism

Nature Aging7 Apr

Extracellular vesicles derived from senescent hepatocytes drive pan-cancer metastasis in aging

Experiments in miceCancer

bioRxiv16 Jul

Downregulation of LATS1/2 Drives Endothelial Senescence-Associated Stemness (SAS) and Atherothrombotic Lesion Formation

Preprint: study in peopleCellular senescence