SPRY1

1. SPRY1 increases inflammation in mouse cells.

   “Knockdown of SPRY1 in RAW264.7 cells resulted in a shift from M1 to M2 macrophage polarization, reduced oxidative stress, and decreased expression of inflammatory markers.”

   CellsknockdownRAW264.7 cells

   SPRY1 regulates macrophage M1 polarization in skin aging and melanoma prognosis

   Translational oncology·Feb 28, 2025

More on Inflammation

1. SPRY1 increases oxidative stress and ROS signalling in mouse cells.

   “Knockdown of SPRY1 in RAW264.7 cells resulted in a shift from M1 to M2 macrophage polarization, reduced oxidative stress, and decreased expression of inflammatory markers.”

   CellsknockdownRAW264.7 cells

   SPRY1 regulates macrophage M1 polarization in skin aging and melanoma prognosis

   Translational oncology·Feb 28, 2025

More on Oxidative stress and ROS signalling

1. TET3 inhibits SPRY1 in human cells.

   “TET3-siRNA upregulated SPRY1 expression in HaCaT cells.”

   Cellsin HaCaT cells

   Association between SPRY1 and TET3 in skin photoaging and natural aging mechanisms

   Journal of cosmetic dermatology·Dec 6, 2023

More on TET3

1. SPRY1 is associated with survival in silico.

   “Additionally, SPRY1 expression was downregulated in melanoma, and its reduced levels were associated with poorer survival outcomes.”

   In silicomelanoma

   SPRY1 regulates macrophage M1 polarization in skin aging and melanoma prognosis

   Translational oncology·Feb 28, 2025

1. Age is associated with SPRY1 in human cells.

   “SPRY1 expression increased with age, whereas TET3 expression decreased.”

   Cellsskin

   Association between SPRY1 and TET3 in skin photoaging and natural aging mechanisms

   Journal of cosmetic dermatology·Dec 6, 2023