1 paper4 findings
Caloric restriction
downin mice1
Caloric restriction decreases DNAmAge in mice.
“was decreased in response to caloric restriction.”
Animals
A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin
eLife12 Nov 2020
Chronological age
upin mice1upin rats1
DNAmAge is associated with chronological age in mice (r = 0.79).
“DNAmAge was also found to correlate with age in male C57BL/6 mice (r = 0.79)”
Animalsmales
A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin
eLife12 Nov 2020
DNAmAge is associated with chronological age in rats (r = 0.93).
“This measure correlated with age at (r = 0.93) in an independent sample”
Animalsin an independent sample
A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin
eLife12 Nov 2020
Physical functioning
upin rats1
DNAmAge is associated with physical functioning in rats (p=5.9e-3).
“related to physical functioning (p=5.9e-3), after adjusting for age and cell counts.”
Animalsafter adjusting for age and cell counts
A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin
eLife12 Nov 2020
Cell counts explain less variation in age acceleration and only modestly affect its links to mortality and 176 incident health outcomes.Cell counts explain less variation in age acceleration and only modestly affect its links to mortality and 176 incident health outcomes.