SLC9A7

1. SLC9A7 protects against endometrial cancer in mice.

   “NHE7-overexpressing macrophages effectively abrogate exogenous lactate-accelerated xenograft tumor growth, as well as its M2 polarization and senescence.”

   Animalsin exogenous lactate-treated xenografts

   Lactate transmission from hypoxic tumor cells promotes macrophage senescence and M2 polarization via the DNMT1-NHE7 axis to accelerate endometrial cancer progression

   Cell death & disease·30 Jan 2026

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