sir-2.2

sir-2.2 has no effect on pharyngeal pumping in worms.

“we did not find evidence of reduced pharyngeal pumping.”

Model organismsin sir-2.2 and sir-2.3 mutants

Mitochondrial sirtuins sir-2.2 and sir-2.3 regulate lifespan in C. elegans

Genetics·5 Sep 2025

sir-2.2 shortens lifespan in worms.

“we demonstrate that sir-2.2 and sir-2.3 mutants live an average of 25% longer than controls when fed the normal lab diet of live E. coli OP50.”

Model organismsdeletion of catalytic activity, fed live E. coli OP50

Mitochondrial sirtuins sir-2.2 and sir-2.3 regulate lifespan in C. elegans

Genetics·5 Sep 2025