SIGIRR
- 2 independent labs in 1 country
- Humans2
- Cells1
Effects
1Clearance of transforming, transformed, dead and dying cells
upin cells1
1 study
Clearance of transforming, transformed, dead and dying cells
upin cells1
SIGIRR increases clearance of transforming, transformed, dead and dying cells in cells.
“We describe a function for the TIR domain TLR/IL-1 family receptor SIGIRR (TIR8) in clearance of transforming, transformed, dead and dying cells”
Cells
SIGIRR functions in senescence and transformation
Zenodo (CERN European Organization for Nuclear Research)Preprint
Associations
1Executive function decline
mixedin humans1
1 study
Executive function decline
mixedin humans1
SIGIRR is associated with executive function decline in humans.
“SIGIRR, PLA2G4A , and HPN all had high impact variants contributing to the gene score that were significantly associated with executive function decline.”
Humanslate-life cognitive performance cohort56% femalesn = 8,481
Rare variant associations with late‐life cognitive performance
AAIC 2025 abstract
Latest
2 papers in 12 monthsAAIC 2025 Abstract
Rare variant associations with late‐life cognitive performance
Genetic association study of 8,481 peopleMechanisms
Biology of Reproduction
Age-related integrative transcriptomic profiling of human granulosa cells reveals mRNA-microRNA regulatory network associated with key ovulation dynamics†
Cohort study in peopleMechanisms