ADAM8

2 papers2 findings

HGNC NCBI Gene Taxon

1 lab in 1 country

Funders: National Institute of Arthritis and Musculoskeletal and Skin Diseases and 1 more

Humans1
Animals1

Effects

2

Cxcl1, Il6, and Adam8 gene expression

downin mice1

1 study

ADAM8 decreases Cxcl1, Il6, and Adam8 gene expression in mice.
“Cxcl1, Il6, and Adam8 gene expression levels were higher in the injured tail IVDs of 3-month-old Adam8EQ than WT mice (n = 18-30; p < 0.05)”
Animalsshown by higher expression in Adam8EQ inactivation mutants than wild-type mice after injurytail intervertebral disc1 week post injury
Effects of Age on Intervertebral Disc Tissue Morphology and Gene Expression in the ADAM8-Inactivation Mouse
Cells20 Apr 2026

More on Cxcl1, Il6, and Adam8 gene expression

Intervertebral disc histology

no changein mice1

1 study

ADAM8 has no effect on intervertebral disc histology in mice.
“No histological differences were found between Adam8EQ and WT mouse IVDs at 3, 10 or 18 months of age, in the intact or injured discs.”
AnimalsAdam8EQ mutation compared with wild type; intact and injured discsintervertebral disc
Effects of Age on Intervertebral Disc Tissue Morphology and Gene Expression in the ADAM8-Inactivation Mouse
Cells20 Apr 2026

Latest

1 in 12 months

Cells27 Apr

Effects of Age on Intervertebral Disc Tissue Morphology and Gene Expression in the ADAM8-Inactivation Mouse

Experiments in miceMechanisms

Biology of Reproduction21 Feb

Age-related integrative transcriptomic profiling of human granulosa cells reveals mRNA-microRNA regulatory network associated with key ovulation dynamics†

Cohort study in peopleMechanisms