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SERPINB3

Gene

2 papers4 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Associazione Italiana per la Ricerca sul Cancro and 2 more
  • Animals1
  • In silico1

Effects

4

MTOR

upin mice1

1 study

  1. SERPINB3 increases MTOR in mice.

    “In addition, TG males showed higher expression of mTOR in the liver.”

    Animalsin SB3 transgenic male micelivermales

    SERPINB3 is associated with longer survival in transgenic mice

    Scientific reports28 Oct 2013

More on MTOR

SHC1

downin mice1

1 study

  1. SERPINB3 decreases SHC1 in mice.

    “In TG mice decreased IL-6 in serum and lower p66shc in the liver were observed.”

    Animalsin SB3 transgenic miceliver

    SERPINB3 is associated with longer survival in transgenic mice

    Scientific reports28 Oct 2013

More on SHC1

IL-6

downin mice1

1 study

  1. SERPINB3 decreases IL-6 in mice.

    “In TG mice decreased IL-6 in serum and lower p66shc in the liver were observed.”

    Animalsin SB3 transgenic miceserum

    SERPINB3 is associated with longer survival in transgenic mice

    Scientific reports28 Oct 2013

More on IL-6

Lifespan

upin mice1

1 study

  1. SERPINB3 extends lifespan in mice (18.5% in males, 12.7% in females).

    “Transgenic (TG) mice showed longer survival than controls and the difference was more remarkable in males than in females (18.5% vs 12.7% life span increase).”

    Animalstransgenic overexpression

    SERPINB3 is associated with longer survival in transgenic mice

    Scientific reports28 Oct 2013

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