SENESCENCE/APOPTOSISGENES

somatic instability increases SENESCENCE/APOPTOSISGENES in humans.

“Striatal pallidal neurons (SPNs) with 150-500 + CAG repeats seem to lose positive and then negative features of neuronal identity, de-repress senescence/apoptosis genes, ultimately leading to cell death.”

Reviewwith 150-500 + CAG repeatsstriatal pallidal neurons

Update on Genetic Chorea

Current neurology and neuroscience reports·4 Jul 2026