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Rogue

There are 2 papers on Rogue in aging research: none in people yet, 2 in animals. The newest story, Oct 28, 2026: “A protein network fails to preserve gut cell identity in aging flies”.

Gene

2 papers study it3 findings

Taxon

1 new paper in 30 daysSee all 2

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: H2020 European Research Council and 5 more
  • Model organisms2

Effects

3

Kdoprotein

downin flies1

1 study

  1. Rogue decreases Kdoprotein in flies.

    “Rogue binds to the RNA transcripts of dUbcH8/Kdo and eEF2, shortening their poly(A) tail and suppressing Kdo protein”

    Model organismsenterocyte

    A protein network fails to preserve gut cell identity in aging flies

    Genes & development

More on Kdoprotein

Enterocyte identity

downin flies1

1 study

  1. Rogue impairs enterocyte identity in flies.

    “the protein Rogue (CG13928), a translational repressor, orchestrates reactivation of a stem-cell-related translational repression machinery involving p-body-associated RNA-binding proteins that cancels the differentiated state”

    Model organismsmidgut

    A Ubiquitin network safeguards cell identity by continuously degrading a stem-cell related translational machinery

    bioRxiv (Cold Spring Harbor Laboratory)Preprint

dUbcH8/Kdo

downin flies1

1 study

  1. Rogue decreases dUbcH8/Kdo in flies.

    “dUbcH8/Kdo and the E3 CTLH complex are cleared via Rogue”

    Model organismsmidgut

    A Ubiquitin network safeguards cell identity by continuously degrading a stem-cell related translational machinery

    bioRxiv (Cold Spring Harbor Laboratory)Preprint

More on dUbcH8/Kdo

Latest

Nov 2025: 0Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 1Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 12 papers in 12 months
Genes & Development

A protein network fails to preserve gut cell identity in aging flies

Experiments in adult flies traced how machinery associated with stem cells became active again with age, undermining mature gut cells’ specialized identity.Experiments in adult flies traced how machinery associated with stem cells became active again with age, undermining mature gut cells’ specialized identity.

Fly studyGut and microbiome
Paper

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