There are 2 papers on Non-stop in aging research: none in people yet, 2 in animals.
- 1 lab in 1 country
- Model organisms2
Effects
3Enterocyte identity
upin flies1is required forin flies1
2 studies
Enterocyte identity
upin flies1is required forin flies1
Non-stop improves enterocyte identity in flies.
“the deubiquitinase Non-stop (dUSP22) and the ubiquitin E2 dUbcH8/Kdo and the E3 enzyme CTLH, together suppress the stem-cell related RNA binding proteins safeguarding EC identity”
Model organismsmidgut
bioRxiv (Cold Spring Harbor Laboratory)Preprint
Non-stop is required for enterocyte identity in flies (RNAi knockdown in young enterocytes).
“acute loss of Non-stop in young ECs phenocopies aged ECs at cellular and tissue levels”
Model organismsRNAi knockdown in young enterocytesmidgut
A Non-stop identity complex (NIC) supervises enterocyte identity and protects from premature aging
eLife
Aging phenotypes
downin flies1
1 study
Aging phenotypes
downin flies1
Non-stop decreases aging phenotypes in flies (maintained youthful Non-stop levels in aged wild-type enterocytes).
“Maintaining youthful levels of Non-stop in wildtype aged ECs safeguards NIC subunits, nuclear organization, and suppressed aging phenotypes”
Model organismsmaintained youthful Non-stop levels in aged wild-type enterocytesoverexpressionmidgut
A Non-stop identity complex (NIC) supervises enterocyte identity and protects from premature aging
eLife
Chromatin accessibility
upin flies1
1 study
Chromatin accessibility
upin flies1
Non-stop increases chromatin accessibility in flies.
“Non-stop ensured chromatin accessibility, maintaining the EC-gene signature, and protected NIC subunit stability”
Model organismsmidgut
A Non-stop identity complex (NIC) supervises enterocyte identity and protects from premature aging
eLife