AgingResearch.NewsJoin free

RNF4

Gene

1 paper2 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Cancer Institute and 3 more
  • Animals1

Effects

2

Tumor susceptibility

no changein mice1

1 study

  1. RNF4 has no effect on tumor susceptibility in mice.

    “Rnf4 deletion caused no increase in tumor susceptibility.”

    AnimalsB cell

    RNF4 sustains Myc-driven tumorigenesis by facilitating DNA replication

    The Journal of clinical investigation26 Mar 2024

Lifespan

downin mice1

1 study

  1. RNF4 shortens lifespan in mice.

    “In contrast, Rnf4 deletion extended the healthy lifespan of mice expressing an oncogenic c-myc transgene.”

    Animalsin mice expressing an oncogenic c-myc transgene

    RNF4 sustains Myc-driven tumorigenesis by facilitating DNA replication

    The Journal of clinical investigation26 Mar 2024

Latest

Related