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RNASE-L

Gene

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: American Federation for Aging Research and 2 more
  • Animals1

Effects

1

Cellular senescence

upin cells1

1 study

  1. RNASE-L induces cellular senescence in cells.

    “Ectopic expression of RNase-L induced a senescent morphology, a decrease in DNA synthesis, an increase in senescence-associated beta-galactosidase activity, and accelerated replicative senescence.”

    Cellsectopic expression

    Role of 2-5A-dependent RNase-L in senescence and longevity

    Oncogene20 Nov 2006

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