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RHEB1

Gene

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: China Postdoctoral Science Foundation and 2 more
  • Humans1

Effects

3

β-cell regeneration

upin reviews1

1 study

  1. RHEB1 increases β-cell regeneration.

    “Rheb1 promotes β-cell regeneration through a dual pathway, activating mammalian target of rapamycin complex 1 and simultaneously inhibiting AMP-activated protein kinase (AMPK).”

    Reviewin diabetes

    Rheb1 as a novel β-cell regulator connecting mTORC1, AMPK, and NOTCH1 pathways for efficient diabetes therapy

    World journal of diabetesAug 15, 2025

Podocyte injury

downin mice1

1 study

  1. RHEB1 protects against podocyte injury in mice.

    “Rheb1 knockout in podocytes aggravated podocyte senescence and injury in diabetic mice”

    Animalsin diabetic mice

    Rheb1 deficiency elicits mitochondrial dysfunction and accelerates podocyte senescence through promoting Atp5f1c acetylation

    Cellular signallingOct 9, 2024

Podocyte senescence

downin mice1

1 study

  1. RHEB1 inhibits podocyte senescence in mice.

    “Rheb1 knockout in podocytes aggravated podocyte senescence and injury in diabetic mice”

    Animalsin diabetic mice

    Rheb1 deficiency elicits mitochondrial dysfunction and accelerates podocyte senescence through promoting Atp5f1c acetylation

    Cellular signallingOct 9, 2024

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