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PUM2

Gene

1 paper3 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Associazione Italiana per la Ricerca sul Cancro and 6 more
  • Animals1

Effects

3

Mitophagy

downin mice1

1 study

  1. PUM2 impairs mitophagy in mice.

    “thereby impairing mitochondrial fission and mitophagy”

    Animalsknockout in muscles of elderly miceskeletal muscle

    The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

    Molecular cell11 Jan 2019

More on Mitophagy

MFF

downin mice1

1 study

  1. PUM2 inhibits MFF in mice.

    “inhibits the translation of the mRNA encoding for the mitochondrial fission factor (Mff)”

    Animals

    The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

    Molecular cell11 Jan 2019

More on MFF

Lifespan

downin mice1

1 study

  1. PUM2 shortens lifespan in mice.

    “acts as a negative regulator of lifespan and mitochondrial homeostasis”

    Animals

    The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

    Molecular cell11 Jan 2019

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