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PKNOX1

Gene

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: European Regional Development Fund and 1 more
  • Cells1

Effects

2

PKCα and eNOS Thr495 phosphorylation

upin mice1

1 study

  1. PKNOX1 increases PKCα and eNOS Thr495 phosphorylation in mice (Prep1 hypomorphic mice: 54% lower PKCα phosphorylation and 60% lower eNOS Thr495 phosphorylation).

    “showed a 54 and 60% decrease in PKCα and eNOSThr495 phosphorylation”

    Animalsshown by Prep1 hypomorphic heterozygosity compared with same-age WT miceaorta

    Resveratrol Improves Endothelial Function by A PREP1-Mediated Pathway in Mouse Aortic Endothelial Cells

    International journal of molecular sciences25 Jul 2023

More on PKCα and eNOS Thr495 phosphorylation

Proinflammatory cytokines

upin mouse cells1

1 study

  1. PKNOX1 increases proinflammatory cytokines in mouse cells (3.5-fold TNF-α; 2.3-fold IL-6).

    “Proinflammatory cytokines Tnf-α and Il-6 increased by 3.5 and 2.3-fold, respectively, in the presence of Prep1”

    CellsPrep1 overexpressionaortic endothelial cell

    Resveratrol Improves Endothelial Function by A PREP1-Mediated Pathway in Mouse Aortic Endothelial Cells

    International journal of molecular sciences25 Jul 2023

More on Proinflammatory cytokines

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