pk

pk is associated with circadian rhythm defects in flies.

“both pk sple and pk pk mutants exhibit circadian rhythm defects”

Model organismsBoth prickle-spiny-legs and prickle-prickle mutants

Drosophila Prickle Mutants Display Comorbid Neurological Phenotypes and Provide A Genetic Link Between Epilepsy and Autism Spectrum Disorder

bioRxiv : the preprint server for biology·23 Jul 2026Preprint

pk is associated with learning and memory deficits in flies.

“a seizure-prone Drosophila prickle mutant ( prickle-spiny-legs , or pk sple ) exhibits learning and memory deficits”

Model organismsSeizure-prone prickle-spiny-legs mutant, but not non-seizure-prone prickle-prickle mutant

Drosophila Prickle Mutants Display Comorbid Neurological Phenotypes and Provide A Genetic Link Between Epilepsy and Autism Spectrum Disorder

bioRxiv : the preprint server for biology·23 Jul 2026Preprint