There are 3 papers on PILRA in aging research: 2 observational studies in people, 1 in animals.
At a glance
The findings reach people, from one lab or study. 1 lab in 1 country.
“negative interactions between PILRA-A and GM17 (OR 0.72, 95% CI 0.52-1.00) and between PILRA-A and APOE risk variants (OR 0.56, 95% CI 0.32-0.98) in the discovery dataset”
None of its findings points the other way.
- 1 lab in 1 country
- Funders: Cure Alzheimer’s Fund and others
- Humans2
- Animals1
Associations
1Alzheimer's disease
downin humans1OR 0.56
1 study
Alzheimer's disease
downin humans1OR 0.56
PILRA is associated with Alzheimer's disease in humans (joint effect with PILRA × GM17/17 in the replication cohort) (p .02).
“In the replication cohort, a joint effect of PILRA and PILRA × GM 17/17 was observed for the risk of developing AD (p .02).”
Humansjoint effect with PILRA × GM17/17 in the replication cohort
PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer's disease risk
Scientific reports
PILRA is linked with a lower risk of Alzheimer's disease in humans (interaction with APOE risk variants (ε3/ε4 or ε4/ε4) in the discovery dataset) (OR 0.56, 95% CI 0.32-0.98).
“negative interactions between PILRA-A and GM17 (OR 0.72, 95% CI 0.52-1.00) and between PILRA-A and APOE risk variants (OR 0.56, 95% CI 0.32-0.98) in the discovery dataset”
Humansinteraction with APOE risk variants (ε3/ε4 or ε4/ε4) in the discovery datasetn = 360
PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer's disease risk
Scientific reports