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PHF8

Gene

2 papers1 finding

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Agence Nationale de la Recherche and 7 more
  • Model organisms1
  • Cells1

Effects

1

Cellular senescence

mediatesin human cells1

1 study

  1. PHF8 mediates cellular senescence in human cells.

    “Screening of iron-dependent DNA and histones demethylases revealed a role for histone PHF8 demethylase in mediating ELN downregulation-induced senescence.”

    CellsELN downregulation

    A non-canonical role of ELN protects from cellular senescence by limiting iron-dependent regulation of gene expression

    Redox biologyMay 22, 2024

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