per

per protects against premature death in flies.

“The arrhythmic period ( per ) gene null mutation exacerbates the age-dependent loss of DA neurons and, in combination with brief oxidative stress, causes premature animal death.”

Model organismsshown by per null mutation combined with brief oxidative stress

Circadian clock disruption promotes the degeneration of dopaminergic neurons

bioRxiv (Cold Spring Harbor Laboratory)·17 Oct 2022Preprint