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PDZK1

Gene

1 paper4 findings

HGNC 8821NCBI Gene 5174Taxon 9606

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Animals1

Effects

4

Oxidative stress and ROS signalling

downin mouse cells1

1 study

  1. PDZK1 decreases oxidative stress and ROS signalling in mouse cells.

    “which is closely related to reducing oxidative stress and enhancing autophagy flux.”

    Cellshigh-glucose stimulationretinal pigment epithelium

    PDZK1 Protects Against RPE Senescence by Targeting the 14-3-3ε-mTOR Axis to Attenuate Early Diabetic Retinopathy

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)25 Aug 2025

More on Oxidative stress and ROS signalling

Autophagy

upin mouse cells1

1 study

  1. PDZK1 increases autophagy in mouse cells.

    “which is closely related to reducing oxidative stress and enhancing autophagy flux.”

    Cellshigh-glucose stimulationretinal pigment epithelium

    PDZK1 Protects Against RPE Senescence by Targeting the 14-3-3ε-mTOR Axis to Attenuate Early Diabetic Retinopathy

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)25 Aug 2025

More on Autophagy

Diabetic retinopathy

downin mice1

1 study

  1. PDZK1 protects against diabetic retinopathy in mice.

    “PDZK1 overexpression-mediated senescence inhibition and Nutlin-3a-induced clearance of senescent RPE cells successfully downregulate retinal senescence markers and improve early-stage DR lesions.”

    Animalsstreptozotocin-induced diabetic retinopathyretinal pigment epithelium

    PDZK1 Protects Against RPE Senescence by Targeting the 14-3-3ε-mTOR Axis to Attenuate Early Diabetic Retinopathy

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)25 Aug 2025

More on Diabetic retinopathy

Cellular senescence

downin mouse cells1

1 study

  1. PDZK1 decreases cellular senescence in mouse cells.

    “Overexpression of PDZK1 reduces senescence markers in RPE cells, promoting cell proliferation and transport functions.”

    Cellshigh-glucose stimulationretinal pigment epithelium

    PDZK1 Protects Against RPE Senescence by Targeting the 14-3-3ε-mTOR Axis to Attenuate Early Diabetic Retinopathy

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)25 Aug 2025

More on Cellular senescence

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