PDRG1
None of its findings points the other way.
- 1 lab in 1 country
- Animals1
Effects
4Cellular senescence
downin human cells1
1 study
Cellular senescence
downin human cells1
PDRG1 inhibits cellular senescence in human cells.
“reveal an epigenetic mechanism by which PDRG1 cooperates with EZH2 to repress p21 and bypass senescence.”
Cellscooperation with EZH2 to repress p21hepatocellular carcinoma cell
International journal of biological sciences
CDKN1A transcription
downin human cells1
1 study
CDKN1A transcription
downin human cells1
PDRG1 decreases CDKN1A transcription in human cells.
“Mechanistically, PDRG1 directly interacted with EZH2, increased H3K27me3 enrichment at the p21 promoter, and suppressed p21 transcription.”
Cellshepatocellular carcinoma cell
International journal of biological sciences
H3K27me3 enrichment at the P21 promoter
upin human cells1
1 study
H3K27me3 enrichment at the P21 promoter
upin human cells1
PDRG1 increases H3K27me3 enrichment at the P21 promoter in human cells.
“Mechanistically, PDRG1 directly interacted with EZH2, increased H3K27me3 enrichment at the p21 promoter, and suppressed p21 transcription.”
Cellshepatocellular carcinoma cell
International journal of biological sciences
Tumor growth
upin animals1
1 study
Tumor growth
upin animals1
PDRG1 increases tumor growth.
“Functionally, PDRG1 enhanced HCC cell proliferation, migration, invasion, colony formation, and tumor growth in vivo.”
Animalssubcutaneous hepatocellular carcinoma xenograft models
International journal of biological sciences
Associations
1Patient survival
downin humans1
1 study
Patient survival
downin humans1
PDRG1 is associated with patient survival in humans.
“PDRG1 was significantly upregulated in HCC tumor tissues compared with adjacent non-tumor liver tissues and was associated with worse patient survival.”
Humanshepatocellular carcinomaliver tumor tissue
International journal of biological sciences