H3K27me3 enrichment at the P21 promoter

1 paper studies it1 finding

Animals1

Upstream

1

PDRG1

upin human cells1

1 study

PDRG1 increases H3K27me3 enrichment at the P21 promoter in human cells.
“Mechanistically, PDRG1 directly interacted with EZH2, increased H3K27me3 enrichment at the p21 promoter, and suppressed p21 transcription.”
Cellshepatocellular carcinoma cell
Identification of a Novel PDRG1-EZH2-p21 Pathway Controlling Senescence and Tumor Progression in Hepatocellular Carcinoma
International journal of biological sciencesFeb 18, 2026

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International Journal of Biological SciencesFeb 18

Identification of a Novel PDRG1-EZH2-p21 Pathway Controlling Senescence and Tumor Progression in Hepatocellular Carcinoma

Experiments in animalsCellular senescence