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PDE2A

Gene

1 paper2 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • 2 of 2 findings with company ties
  • Animals1

Effects

2

Dendritic mushroom and thin spine density

downin mice1

1 study

  1. PDE2A decreases dendritic mushroom and thin spine density in mice.

    “is paralleled by increased density of dendritic mushroom and thin spines in hippocampal CA3 and dentate gyrus in adult mice.”

    Animalsshown by heterozygous Pde2a knockouthippocampal CA3 and dentate gyrus

    Longevity, enhanced memory, and altered density of dendritic spines in hippocampal CA3 and dentate gyrus after hemizygous deletion of Pde 2a in mice

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology27 Nov 2024

More on Dendritic mushroom and thin spine density

Spatial and object recognition memory

downin mice1

1 study

  1. PDE2A impairs spatial and object recognition memory in mice.

    “The mice exhibit enhanced spatial and object recognition memory that is independent of anxiolytic effects”

    Animalsshown by heterozygous Pde2a knockout

    Longevity, enhanced memory, and altered density of dendritic spines in hippocampal CA3 and dentate gyrus after hemizygous deletion of Pde 2a in mice

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology27 Nov 2024

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